RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0018289 Details
Basic Information
circRNA    hsa_circ_0018289
Alias    -
circBase ID    hsa_circ_0018289
Host gene    SYT15
Species    homo sapiens
Peptide    -
Sequence  AGCAGCTGGCCCTGGTGATTGGGGGCACCATCGGGGGGCTGCTGCTGCTGCTGTTGATCGGGGCAAGCTGCTGTCTGTGGAGAAGGTTCTGTGCCACCCTCACCTATGAGGAGCTGCCTGGGACACCAGCCATGGCCACCACAGCTGCCTCCAGTGGGCAGCGGGACAGGCCCTGCCAGCCGCATGCTAGGACCCAACTGAGCAGGCCACCAGCTGTGCCATTCGTGGTGCCCCCAACCCTTCAAGGCCGAGATTGGGTGCCCCTGCACAGTGGAGAGTGGGCCGATGCCCCATGGGACCCCTGCCCGGCATCAGAGCTGCTGCCTCACACCTCCAGCGGCGGCCTTG
Expression
Description  hsa_circ_0018289 expression was upregulated in cervical cancer
Method    microarray, qRT-PCR
Sample    pairs of cervical cancer tissue and adjacent noncancerous tissue, HeLa, CaSki, SiHa, HT-3, C33A, HaCaT
Function
Description  hsa_circ_0018289 knockdown inhibited the proliferation, migration and invasion of cervical cancer cells in vitro and in vivo
Method    loss of function
in vitro    HeLa, SiHa
in vivo    male BALB/c nude mice (6 weeks)
Interaction
Target    miR-497
Type    circRNA-miRNA
Sample    HEK293T
Experiment    luciferase reporter assay
Description    The decreasing of luciferase intensity when hsa_circ_0018289 vector combined with miR-497.
ceRNA target    -
Reference
Pubmed ID    29156822
Trait/Disease    Cervical Cancer
Title    Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis.
Authors    Gao YL, Zhang MY, Xu B, Han LJ, Lan SF, Chen J, Dong YJ, Cao LL.
Journal    Oncotarget. 2017