RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_000984 Details
Basic Information
circRNA    hsa_circ_000984
Alias    CDK6, hsa_circ_000984
circBase ID    hsa_circ_0001724
Host gene    CDK6
Species    homo sapiens
Peptide    -
Sequence  GGCAGGAGCGCGCGGAGGGTAGCGATGGAGGCTTCGTAAAGGAGGAGGAGGGGAGTCTGGAGGAACCCCGAGGAAGGCTTCTGGGCTGTCTGATTGCACTTTCTTCTTATCCTCCCGTCTCCTCCTTTAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGGACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGCGGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGCGGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCCCCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTG
Expression
Description  hsa_circ_000984 was remarkably upregulated in the tissues of colorectal cancer (CRC) patients and in the CRC cell lines.
Method    qRT-PCR
Sample    CRC tumors and matched adjacent normal tissues, CCD-18Co, InEpC, SW480, SW620 and HT29 cells
Function
Description  hsa_circ_000984 knockdown could inhibit cell proliferation, migration, invasion in vitro and tumor formation in vivo in CRC cell lines.
Method    loss of function
in vitro    SW480, SW620
in vivo    nude mice
Interaction
Target    miR-106b
Type    circRNA-miRNA
Sample    CRC tumors and matched adjacent normal tissues
Experiment    expression
Description    miR-106b was highly expressed in CRC tissue samples (P<0.01), and its expression was positively correlated with hsa_ circ_000984 expression in CRC samples.
ceRNA target    CDK6
Reference
Pubmed ID    29207676
Trait/Disease    Colorectal Cancer
Title    Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b.
Authors    Xu XW, Zheng BA, Hu ZM, Qian ZY, Huang CJ, Liu XQ, Wu WD.
Journal    Oncotarget. 2017