RefCirc
a reference database for circRNAs validated by experiments

circRNA_100782 Details
Basic Information
circRNA    circRNA_100782
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  circRNA_100782 was markedly upregulated in PDAC.
Method    qRT-PCR
Sample    BxPC3 and HPDE
Function
Description  Knockdown of circRNA_100782 inhibited cell proliferation by downregulating the microRNA-124 (miR-124) target genes interleukin-6 receptor (IL6R) and signal transducer and activator of transcription 3 (STAT3). CircRNA _100782 knockdown repressed BxPC3 xenograft growth in vivo.
Method    loss of function
in vitro    BxPC3
in vivo    6-week-old male BALB/c nude mice
Interaction
Target    miR-124
Type    circRNA-miRNA
Sample    HEK293T
Experiment    luciferase reporter assay
Description    luciferase assay revealed that miR-124 was a direct target of circRNA_100782.
ceRNA target    IL6R and STAT3
Reference
Pubmed ID    29255366
Trait/Disease    Pancreatic Carcinoma
Title    CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway.
Authors    Chen G, Shi Y, Zhang Y, Sun J.
Journal    Onco Targets Ther. 2017