RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0005015 Details
Basic Information
circRNA    hsa_circ_0005015
Alias    -
circBase ID    hsa_circ_0005015
Host gene    HAS2
Species    homo sapiens
Peptide    -
Sequence  ATGCATTGTGAGAGGTTTCTATGTATCCTGAGAATAATTGGAACCACACTCTTTGGAGTCTCTCTCCTCCTTGGAATCACAGCTGCTTATATTGTTGGCTACCAGTTTATCCAAACGGATAATTACTATTTCTCTTTTGGACTGTATGGTGCCTTTTTGGCATCACACCTCATCATCCAAAGCCTGTTTGCCTTTTTGGAGCACCGAAAAATGAAAAAATCCCTAGAAACCCCCATAAAGTTGAACAAAACAGTTGCCCTTTGCATCGCTGCCTATCAAGAAGATCCAGACTACTTAAGGAAATGTTTGCAATCTGTGAAAAGGCTAACCTACCCTGGGATTAAAGTTGTCATGGTCATAGATGGGAACTCAGAAGATGACCTTTACATGATGGACATCTTCAGTGAAGTCATGGGCAGAGACAAATCAGCCACTTATATCTGGAAGAACAACTTCCACGAAAAGGGTCCCGGTGAGACAGATGAGTCACATAAAGAAAGCTCGCAACACGTAACGCAATTGGTCTTGTCCAACAAAAGTATCTGCATCATGCAAAAATGGGGTGGAAAAAGAGAAGTCATGTACACAGCCTTCAGAGCACTGGGACGAAGTGTGGATTATGTACAG
Expression
Description  Upregulated in diabetic human retinas compared to nodiabetic retinas.
Method    microarray, qRT-PCR
Sample     diabetic human retinas, nodiabetic retinas
Function
Description  -
Method    -
in vitro    -
in vivo    -
Interaction
Target    miR-519d-3p
Type    circRNA-miRNA
Sample    human retinal vascular endothelial cells
Experiment    luciferase reporter assay
Description    Luciferase activity assays showed that miR-519d-3p, but not miR-6505-3p, miR-548an, miR-498, or miR-758 mimicked transfection and decreased the activity of LUC-circ_0005015 after 48 hours transfection.
ceRNA target    MMP-2, STAT3, and XIAP
Reference
Pubmed ID    29288268
Trait/Disease    Diabetic Retinopathy
Title    Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.
Authors    Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B.
Journal    Invest Ophthalmol Vis Sci. 2017