RefCirc
a reference database for circRNAs validated by experiments
| hsa_circ_0021001 Details |
| Basic Information |
| circRNA | hsa_circ_0021001 |
| Alias | - |
| circBase ID | hsa_circ_0021001 |
| Host gene | ARFIP2 |
| Species | homo sapiens |
| Peptide | - |
| Sequence | GGTGCTGGGGTGGAGAGTTTTACTCCAATACCTTTCCTAGCCATGACGGACGGGATCCTAGGGAAGGCAGCCACAATGGAGATCCCTATCCACGGGAACGGCGAAGCCAGGCAGCTTCCTGAAGATGATGGGCTGGAGCAGGACCTCCAGCAGGTGATGGTGTCAGGACCCAACCTCAATGAAACCAGCATTGTGTCTGGTGGCTATGGGGGCTCTGGTGATGGACTCATCCCCACAGGGAAGTCAATTTCATGTGCTCGAAGAGAAGTATGGGTGGGGCCACAGAGGTGTCTGGTGTATCTGAGAGAGGCTGGTGTCAGAGAACTTGATCCTTTAGGGTCTGGCCGCCATCCATCTCACAGCACCACTCCTTCTGGCCCTGGAGATGAGGTGGCTCGGGGCATTGCTGGAGAAAAGTTTGACATCGTCAAGAAATGGGGCATCAACACCTATAAGTGCACAAAGCAACTGTTATCAGAACGATTTGGTCGAGGCTCACGGACTGTGGACCTGGAGCTAGAGCTGCAGATTGAGTTGCTGCGTGAGACGAAGCGCAAGTATGAGAGTGTCCTGCAGCTGGGCCGGGCACTGACAGCCCACCTCTACAGCCTGCTGCAGACCCAGCATGCACTGGGTGATGCCTTTGCTGACCTCAGCCAGAAGTCCCCAGAGCTTCAG |
| Expression |
| Description | Hsa_circ_0021001 level in the peripheral blood of IA patients was relatively lower than that in the control group (P=0.002). The area under ROC (AUC) was 0.87, indicating that hsa_circ_0021001 was highly effective in the diagnosis of IA. In addition, hsa_circ_0021001 expression was correlated with aneurysm rupture, Hunt, Hess level, and timing of surgery (P= 0.041, 0.013, and 0.001, respectively). Patients with high expression of hsa_circ_0021001 had longer disease-free survival (DFS) and overall survival (OS) (P < 0.05). We found for the first time that hsa_circ_0021001 decreased significantly in the peripheral blood of IA patients, which suggested that hsa_circ_0021001 might be used as a potential novel marker for the diagnosis of IA. |
| Method | qRT-PCR |
| Sample | Peripheral blood of IA patients and healthy volunteers |
| Reference |
| Pubmed ID | 29291016 |
| Trait/Disease | Intracranial Aneurysm |
| Title | Circular RNA hsa_circ_0021001 in peripheral blood: a potential novel biomarker in the screening of intracranial aneurysm. |
| Authors | Teng L, Chen Y, Chen H, He X, Wang J, Peng Y, Duan H, Li H, Lin D, Shao B. |
| Journal | Oncotarget. 2017 |