RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0001649 Details
Basic Information
circRNA    hsa_circ_0001649
Alias    hsa_circ_001599
circBase ID    hsa_circ_0001649
Host gene    SHPRH
Species    homo sapiens
Peptide    -
Sequence  GGCAGCCATTCTACAAAAGTGGAAGCTGTGGTCAGAACTCTGATGAAAATACAGCTTAGAGATCCAGGGGCCAAAGCACTCGTTTTCTCAACGTGGCAAGATGTATTAGATATTATTTCAAAAGCTCTTACTGACAACAACATGGAATTTGCACAAATCAGTCGTGTTAAGACATTTCAGGAGAACCTTTCAGCATTTAAACGTGATCCCCAAATCAATATTTTGCTGCTGCCCCTGCACACAGGTTCTAATGGATTAACTATCATTGAAGCAACTCATGTTCTCTTGGTGGAGCCCATATTGAACCCTGCCCATGAGCTTCAGGCCATAGGGAGGGTGCACCGAATTGGACAGACAAAACCTACTATTGTACACAGATTCTTAATTAAAGCAACAATAGAAGAAAGAATGCAGGCAATGCTGAAAACTGCTGAGAGAAG
Expression
Description  Hsa_circ_0001649 is downregulated in both CCA tissues and cell lines.
Method    qRT-PCR
Sample    HCCC-9810, RBE, CCLP1, HuCCT1, Huh-28, KMBC, QBC939 and human intrahepatic biliary epithelial cell (HIBEC), CCA tissues and the normal counterparts
Function
Description  Downregulated hsa_circ_0001649 is linked to aggressive tumor phenotypes in CCA. Hsa_circ_0001649 regulates cell proliferation in CCA cells. Downregulated hsa_circ_0001649 attenuates CCA cell apoptosis. Hsa_circ_0001649 influences CCA cell migration and invasion capacities. Upregulated hsa_circ_0001649 suppresses tumor growth in vivo.
Method    loss of function, gain of function
in vitro    KMBC, Huh-28
in vivo    6-week-old BALB/c nude mice
Interaction
Target    -
Type    -
Sample    -
Experiment    -
Description    -
ceRNA target    -
Reference
Pubmed ID    29337065
Trait/Disease    Cholangiocarcinoma
Title    Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells.
Authors    Xu Y, Yao Y, Zhong X, Leng K, Qin W, Qu L, Cui Y, Jiang X.
Journal    Biochem Biophys Res Commun. 2018