RefCirc
a reference database for circRNAs validated by experiments

circVMA21 Details
Basic Information
circRNA    circVMA21
Alias    -
circBase ID    hsa_circ_0091702
Host gene    VMA21
Species    homo sapiens
Peptide    -
Sequence  GCGCCCTTGGGATGTCCAATAGGGACAGCTATTTTTACGCTGCTATTGTTGCAGTGGTCGCCGTCCATGTGGTGCTGGCCCTCTTTGTGTATGTGGCCTGGAATGAAGGCTCACGACAGTGGCGTGAAGGCAAACAGGATTAAAGTGAACATCACCTTTTTATAGCATTAAATTCATTTTTTAAAATGATAAATGCTGGAGGGGGCCATCTGATTTGAATAAAGTTGAAAGAACATGTTAAAGTCAGTCTTAAGGAGTCACGTTTGAGTATGTAAATTTTGATCTTTCTAATATGTTGGTTTGTATATTCAGTTTTAACTGTATGAATCTGATTTGCAAATGAGAATTTGGAAAAGTTAGTTACAAAGAAATATGTTAATTTAATTAGACAATACTCTGGAAGGAATTTTATCTTCTTTCAACAAAACATGTTTTATAGTATTCTGACTTACGGTTGCTTTTGAGTTTTACTCATTTGGATATATTAAGATGCACACAGTGAAGCAAATTAAACTCCACTTTACGCTGGAATGCTTTCTTTAGCATGAAAATACCAGGTCCTTGGATTTGGGATTTTAATTTCCTATGGAAAGTTGCTTAAATTGTGGACACTGGAATTAATCTGAATGTCACTGAGGAATTTCACATGAAGTGTAATCCCTAGTCAATAAGAATTATCCATTACATTATTTTATGGGAAAACTAGGCTAAATTACATCCATTCAGGTAAAAGGACCTTAGCTTACTGAAGGATCTAAAGAGCAAAGCAAAGATCTCACTACTCAAACACTCAGCCTGCTTCCTTCAAGTCCCCTTGCAGGCCAGCTTTGTGCTTTGCAGACCAACTTTTTAATGAGATACTTTGCTTCCTCATTCAACATTGAAGCTAGGCTTCAATTAAAAGGTTCGAGGAAGCTCCATTTAAAATTGTTTTTTTTACTATTTTTTAAAATTGTAGTGTATATGATAGGAATTTGCATTTAAATATGTTCATTTTTGCATATGTTAGGAGTGGAAACAATCTGGAAAACATTTTTTTTTCATCCAAAAAGTATTCTCCTTGGGCATATCTGATGGAAAAAAACCTTGATTTTATTTTCGTATCTTTAGTCTGTGTTCTTTCTAGTTATTTGGTACTAATTATGTGCAATCTAAAAACACTCCCACAAGTATTTGTTTTTTAATTATAAAATCATAGTATATGTTCTTTGTAGAAAACTGGAAAAATACATATTCAAACAGGAAAAAAAATCAAAATTCCCCATAATGTTGCCATCTAAAAATAACCTCTATTTTAGTTGATATCCCGTATTCATTTTTGAAAGCCATTCCTTAATGCTAGTTTGATACACACTAAAAGTTTAGCTTACAAGTTCAAATTCTGCCAGCTTTTCCTGACAGCTATTTGCATTTTTTTCAGATGAGTGATTATTGGCCATTTTCTTTTTCTTTTTCTTTATTTTATTTATTTATTTTTTTGAGACAGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCACCTCAGCCTCCCAAGTAGCTGGGACTACGGATGCCTGCCACCACGCCTGGCTAATTTTTTTTTGTATTTTTTTGTAGAGACGGGGTTTCACCATGTTGTCCAGGCTAATCTTGAACTTGTGACCTCAGGTGATCCACCCGCCTCGGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCTACCACGCCCGGCCTTATTGACCATTTTCTAAATAAGCACATTCTATCTTTATTCTCTTAAAATTCAAATTTTCTGTTACTGATAATCCTAATACTAGGATTCTTGCTTAAGTATGTGAAACCATTACCGATTTGTTGTTCACATTTATTTTTTATGTTGTGAAACTGGACTAAAGGAATAGAGGGATGATTAGTCATAAAAGTCAAATAGCATTTGTGTTTAACTGTTGAGAAAAGTGAAAGATCAGTATGATTATTATGGAACTGTTTTTAATTCTTGCTTAAAGACTACAATTTTAGTATAATGACATTTGAGTCTAGGGTAGTATGTGGTAGATTTCTAGATGGTCCCTAATTAAGAAGTATTGTTGTATTTAGAATTGTCCACCTAATTTCTTTTTATATAATGCCAAGGTATTTCTTGTGCTTTTGGGATCTTATGCTGTTTGTAAAATGTTACTGTCCAATGTTGGATTATTGTTTTGGTTTCAGGCATTTGCTGAATAGGTGATGATACATGGGTATTTTTCTGCAAGTATTTAAACCAGGGGCATATGCAAAGGCAGTTGTAATTTCCTCTTGGAAAAAGCGCCAAATGTTTGAAGGTTAAAATCAAATGCTAGGGTTGATATTTAGGCTTATAACAAAATAGGCTTGTTTTCAAAGCAGTTTTTTCCTAGAGTTTTAACTGTTAACTCACTAGTTTGCTGCTGTTTTTAACTATGTTAAATAACATATGGTATTTGGCAAATAGATTTATTTTTCAAAATGTCTCACTAGTTTCCTTTTACACAATGTATATACTTCAAGATGTATAGAAAGGAAAGCTACAGTTGAGCCCTTATACATGTTTTAAGGTAGAAATATGTTCCCTATTGTTTGAAAACTGATTGTAAGAATAACCTCAGTTAGGAGATATAACTTGAAGTGTCAGTCCAAACTACTGATTTAACCCTATTTACGGTAACACATTACCTTCCTCACCTCCTGTTTGGCCCTGGAGAATGTAGTCCTTTTTCTCATTTGTGTTGAGAAATGAAAAGTCTGCTGTAGAATGTATCTGATGTCATTAGTTCTTCAAATGGATACCATTGTACATATAACAGTAGAATTTGGTTTGGGGTTGTTAGTGAAAAAAAATTTAAACCTGCCATTAAAAATCCCCATGTTTCATGGAAATCTAACAGAAATACATTGTAATAATTAGAACATTTTGTTTTCTTTTTTCTTTTTTTTTTTTTCGAGACGGAGTTTTGCCCTTCTTGCCCAGGCTGGAGTGCAAGGGCGCAATCTCGGCTCGCTGCAACCTCCGCCTCCCGGGTTCAAGCAGTTCTCCTGCCTCAGCCCCCTGAGTACCTCAGATGACAGGTGCGTGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCCGCCTCCCAAAGTGCTGGGATTACAGGTATCAGCCACCGTGCCTGGCCTAATAATTGGAACATTTTCATCATGAAAATGTCATCAGCTTTGCCAAAAGAAACAACCAATTGACTTGTTTGGCGTTTGTTTTCCATTTTCATGTCAATTTTATGTATACAGTTAGAATACCCAAGGAGACCACTAAAATCAGTTAAACAAGTAGGGTATATACAAAGAAAGATGAAACCCGAAAGTACATAAAAAGGATTTAAATCCGATTTTAGATGTACCTAGTGTGTATTTCTTATCTCTAGACAAGTTCATGTTTATTGTTTAATTTATGCCCAAGTGAAGTTGTAAACTTATGGTTCAACTCTGACACAGAATTTGTCACTTGTCTGAGGTCAGTGGCAGGTTTCTCTGCTGTCAAGCACTCTGTGTCACCCACCAGATTAGTATAACTATTAATTCAGACTGTACTCCTATGTTTAAGATAATTTTTACAAGAGCTGGCTGAAGCAGCACATTAGTAACCTGACAAGATTTCTTTTTCCCTTTTCAGGGGGAAAGGGTCACCTTAAAAATAAATTATTTTCAGGGACTTTGGGAATCTAATGATAAATATTACACATAATCTATGAATAGCTTAATCCTTTATATATTCCTTAAAATAGGAATTCCTCGACATCACTCCTGGCCACACTTTCCTTGCCTGTGTTGTTGCTATGTGTATTTGAAAGTAATATCTGCATTCCTTTTAAGATGTTCTGTAAGTCATATTTGTCAGTTATACAGAGTAGTCTTCCTTTTCCCCACGTTCAGTGTAATCTCACTGAACAGTAATAATAGCAATAGCTAACAACATCTGCACAGCACCTTACAGTTTGCAAAGAACGTTCACACATTCTCATTTGAGTTTTGCATAGTGAACCTGTTACGAGATGTCTCTTGACGTCGATGCTAAAAGTGTTAGAATCTTTACATCACTAGAGTCATTGAATATGCTGTAGTATTGAATAGTGCCCTGACTAGGGGGAGGATTTGGATGTGCTGCATTTCAAGCCGTGTATAATCATCAAAATGGGGGGCTTGAGTTCTTTAGCTACTTGAATCCGATTTACTTCTGTTAAGTGATGCTTTTCTAACCGTTTTCTGGATGGATTTTGTATTCACTATATTGTAGCTTGTAATTTGTATAAATGTACCATCTGATGTCATTAAAAAAAGTGTTTGTAGTGCTA
Expression
Description  CircVMA21 levels were markedly reduced in the degenerative NP tissues compared with the controls by qRT-PCR analysis. This result was also confirmed by RNA fluorescence in situ hybridisation (FISH).
Method    qRT-PCR,FISH
Sample    rat nucleus pulposus tissue
Function
Description  CircVMA21 acted as a sponge of miR-200c and functioned in NP cells through targeting miR-200c and XIAP. Intradiscal injection of circVMA21 alleviated IVDD in the rat model. CircVMA21 could alleviate inflammatory cytokines-induced NP cell apoptosis and imbalance between anabolism and catabolism of extracellular matrix through miR-200c-XIAP pathway. It provides a potentially effective therapeutic strategy for IVDD.
Method    loss of function
in vitro    nucleus pulposus cells, rat nucleus pulposus tissue
in vivo    IVDs of rat models
Interaction
Target    miR-200c
Type    circRNA-miRNA
Sample    nucleus pulposus cell
Experiment    luciferase report assay, RNA pull-down assay, FISH
Description    circVMA21 was able to directly bind to miR-200c in NPCs
ceRNA target    XIAP
Reference
Pubmed ID    29343508
Trait/Disease    Intervertebral Disc Degeneration
Title    Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein.
Authors    Cheng X, Zhang L, Zhang K, Zhang G, Hu Y, Sun X, Zhao C, Li H, Li YM, Zhao J.
Journal    Ann Rheum Dis. 2018