RefCirc
a reference database for circRNAs validated by experiments

circ-SHPRH Details
Basic Information
circRNA    circ-SHPRH
Alias    -
circBase ID    -
Host gene    SHPRH
Species    homo sapiens
Peptide    MKIQLRDPGAKALVFSTWQDVLDIISKALTDNNMEFAQISRVKTFQENLSAFKRDPQINILLLPLHTGSNGLTIIEATHVLLVEPILNPAHELQAIGRVHRIGQTKPTIVHRFLIKATIEERMQAMLKTAERRAAILQKWKLWSEL
Sequence  -
Expression
Description  We identified a lower-expressed circRNA in glioblastoma, circ-SHPRH, which translated a 146-aa novel protein using overlapping genetic codes.
Method    RNA-seq, qRT-PCR
Sample    Glioma samples and normal brain tissues, U251, U373, 293T
Function
Description  circ-SHPRH encodes a novel protein named SHPRH-146aa. SHPRH-146aa protects full-length SHPRH from degradation by the ubiquitin proteasome. Stabilized SHPRH sequentially ubiquitinates proliferating cell nuclear antigen (PCNA) as an E3 ligase, leading to inhibited cell proliferation and tumorigenicity.
Method    loss of function, gain of function
in vitro    U251, U373, 293T
in vivo    nude mice
Interaction
Target    -
Type    -
Sample    -
Experiment    -
Description    -
ceRNA target    -
Reference
Pubmed ID    29343848
Trait/Disease    Glioblastoma
Title    A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.
Authors    Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N.
Journal    Oncogene. 2018