RefCirc
a reference database for circRNAs validated by experiments

circ-ZFR Details
Basic Information
circRNA    circ-ZFR
Alias    -
circBase ID    -
Host gene    ZFR
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  Circ-ZFR was significantly downregulated in GC tissues and cells
Method    microarray, qRT-PCR
Sample    GC tissues and adjacent tissue samples, GES-1, AGS, AZ521, and HGC-27
Function
Description  Overexpression of circ-ZFR retarded cell propagation and cell cycle and promoted apoptosis in GC. Circ-ZFR curbed GC tumor growth and affected p53 protein expression in vivo.
Method    gain of function
in vitro    AGS
in vivo    male BALB/c Nude mice (8-week-old)
Interaction
Target    miR-107, miR-130a
Type    circRNA-miRNA
Sample    AGS
Experiment    luciferase reporter assay, AGO2 RIP
Description    Overexpression of miR-107 and miR-130a both significantly repressed the luciferase activity of the luciferase reporter containing circZFR 3 UTR-WT but not the reporter containing circZFR 3-UTR-Mut. RIP assay verified that there existed some interactions between circZFR and miR-107/miR-130a both (p<0.05).
ceRNA target    PTEN
Reference
Pubmed ID    29361817
Trait/Disease    Gastric Cancer
Title    Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN.
Authors    Liu T, Liu S, Xu Y, Shu R, Wang F, Chen C, Zeng Y, Luo H.
Journal    Cancer Res Treat. 2018