RefCirc
a reference database for circRNAs validated by experiments

circ-ITCH Details
Basic Information
circRNA    circ-ITCH
Alias    -
circBase ID    -
Host gene    ITCH
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  circ-ITCH is down-regulated in BCa tissues and cell lines.
Method    qRT-PCR
Sample    BCa tumor and normal tissues, EJ and T24 cells
Function
Description  Circ-ITCH inhibited the progression of BCa cells in vitro. circ-ITCH suppressed growth of xenografted tumor in vivo.
Method    gain of function
in vitro    EJ and T24 cells
in vivo    4-6 weeks old female athymic BALB/C nude mice
Interaction
Target    miR-17 and miR-224
Type    circRNA-miRNA
Sample    EJ and T24 cells
Experiment    luciferase reporter assay, RNA FISH
Description    circ-ITCH could directly sponge miR-17 and miR-224.
ceRNA target    p21 and PTEN
Reference
Pubmed ID    29386015
Trait/Disease    Bladder Cancer
Title    Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression.
Authors    Yang C, Yuan W, Yang X, Li P, Wang J, Han J, Tao J, Li P, Yang H, Lv Q, Zhang W.
Journal    Mol Cancer. 2018