RefCirc
a reference database for circRNAs validated by experiments

circRNA_0046366 Details
Basic Information
circRNA    circRNA_0046366
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  Compared to the normal group, the steatosis group exhibited significant loss of circRNA_0046366 expression.
Method    qRT-PCR
Sample    HepG2 cells with (steatosis group) or without (normal group) FFA-induced steatosis
Function
Description  CircRNA_0046366 antagonizes the activity of miR-34a via MRE-based complementation. In contrast to its lowered level during FFA-induced hepatocellular steatosis, circRNA_0046366 up-regulation abolished the miR-34a-dependent inhibition of PPAR?? that played a critical role in metabolic signaling pathways. The circRNA_0046366-related rebalancing of lipid homeostasis led to dramatic reduction of TG content, and resulted in the ameliorated phenotype of hepatocellular steatosis.
Method    gain of function
in vitro    HepG2 cells
in vivo    -
Interaction
Target    miR-34a
Type    circRNA-miRNA
Sample    HepG2 cells
Experiment    luciferase reporter assay
Description    circRNA_0046366 is an antagonist of miR-34a via targeted, complementary binding.
ceRNA target    PPAR??
Reference
Pubmed ID    29391755
Trait/Disease    Hepatocellular Steatosis
Title    circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling.
Authors    Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG.
Journal    World J Gastroenterol. 2018