RefCirc
a reference database for circRNAs validated by experiments

CircHIPK3 Details
Basic Information
circRNA    CircHIPK3
Alias    -
circBase ID    -
Host gene    HIPK3
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  circHIPK3 was upregulated in 41 out of 50 (82%) HCC tissues compared with that in adjacent tissues.
Method    qRT-PCR
Sample    HCC tissues
Function
Description  circHIPK3 regulated the proliferation and migration of HCC cells via the miR-124-AQP3 axis. Knockdown of circHIPK3 suppressed tumor growth in vivo.
Method    loss of function
in vitro    Huh7 and MHCC-LM3 cells
in vivo    Five-week-old nude mice
Interaction
Target    miR-124
Type    circRNA-miRNA
Sample    HEK-293T
Experiment    luciferase reporter assay
Description    Cotransfection of pmirGLO-circHIPK3-WT and miR-124 into HEK293T cells resulted in a reduction in luciferase activity compared with that from the cotransfection of pmirGLO-circHIPK3-MUT and miR-124.
ceRNA target    AQP3
Reference
Pubmed ID    29415990
Trait/Disease    Hepatocellular Carcinoma
Title    circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma.
Authors    Chen G, Shi Y, Liu M, Sun J.
Journal    Cell Death Dis. 2018