RefCirc
a reference database for circRNAs validated by experiments

circRNA-000911 Details
Basic Information
circRNA    circRNA-000911
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  down
Method    microarray, qRT-PCR
Sample    cancer tissues and paired adjacent non-cancerous tissues, MCF 10A, MCF-7, MDA-MB-231, MDA-MB-468, MDA-MB-453, SKBR-3 and T47D
Function
Description  Circular RNA (circRNA)-000911 plays an anti-oncogenic role in breast cancer cells.
Method    loss of function, gain of function
in vitro    MCF-7, MDA-MB-231
in vivo    -
Interaction
Target    miR-449a
Type    circRNA-miRNA
Sample    MCF-7, MDA-MB-231
Experiment    luciferase reporter assay, circRIP
Description    miR-449a significantly inhibited the luciferase activity of the wild-type reporter of cirRNA-000911. We found a specific enrichment of cirRNA-000911 and miR 449a as compared to the controls.
ceRNA target    Notch1
Reference
Pubmed ID    29431182
Trait/Disease    Breast Cancer
Title    Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis.
Authors    Wang H, Xiao Y, Wu L, Ma D.
Journal    Int J Oncol. 2018