RefCirc
a reference database for circRNAs validated by experiments

circ_0067934 Details
Basic Information
circRNA    circ_0067934
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  The expression of circ_0067934 was significantly upregulated in HCC tissues and cell lines compared to adjacent normal tissues.
Method    qRT-PCR
Sample    HCC and adjacent normal tissues, BEL7402, Hep3B, HuH7, MHCC97-L, HL-7702
Function
Description  circ_0067934 knockdown suppressed HCC cell proliferation and metastasis in vitro and in vivo.
Method    loss of function
in vitro    Hep3B and HuH7 cells
in vivo    6-week-old BALB/c nude mice
Interaction
Target    miR-1324
Type    circRNA-miRNA
Sample    Hep3B and HuH7 cells
Experiment    luciferase reporter assay
Description    miR-1324 mimics inhibited the luciferase activity of Hep3B and HuH7 cells transduced with wide type circ_0067934.
ceRNA target    FZD5
Reference
Pubmed ID    29458020
Trait/Disease    Hepatocellular Carcinoma
Title    CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/??-catenin axis.
Authors    Zhu Q, Lu G, Luo Z, Gui F, Wu J, Zhang D, Ni Y.
Journal    Biochem Biophys Res Commun. 2018