RefCirc
a reference database for circRNAs validated by experiments
| circular PVT1 Details |
| Basic Information |
| circRNA | circular PVT1 |
| Alias | - |
| circBase ID | - |
| Host gene | PVT1 |
| Species | homo sapiens |
| Peptide | - |
| Sequence | - |
| Expression |
| Description | strong upregulation of circPVT1 in AML-amp cases with amplicons including PVT1 compared with AML-amp cases in which PVT1 was not amplified (as 07B60) or AML-NK samples. In AML cell lines, a slight upregulation of circPVT1 was observed only in the two cell lines carrying more than five copies of PVT1 (GF-D8 and KG-1). |
| Method | qRT-PCR |
| Sample | AML-amp cases with amplicons including PVT1, AML-amp cases in which PVT1 was not amplified, AML cases with a normal karyotype (AML-NK samples), GF-D8 and KG-1 |
| Reference |
| Pubmed ID | 29467491 |
| Trait/Disease | Acute Myeloid Leukemia |
| Title | MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences. |
| Authors | L Abbate A, Tolomeo D, Cifola I, Severgnini M, Turchiano A, Augello B, Squeo G, D Addabbo P, Traversa D, Daniele G, Lonoce A, Pafundi M, Carella M, Palumbo O, Dolnik A, Muehlematter D, Schoumans J, Van Roy N, De Bellis G, Martinelli G, Merla G, Bullinger L, et al. |
| Journal | Leukemia. 2018 |